Did you know that heart disease and osteoporosis are closely linked — to such an extent that it’s been suggested those with heart disease should be screened for osteoporosis and vice versa? According to emerging science, the two conditions are tied together by one major factor— inflammation.
So that’s why, for February Heart Health Month, I’m recommending you obtain one simple blood test that’s capable of detecting runaway inflammation and its related antioxidant deficit—the C-Reactive Protein (CRP) test. In fact, some authorities suggest that the high-sensitivity CRP test could predict the risk of developing serious heart disease (and other chronic illnesses) years in advance (He et al. 2010; Li et al. 2017).
C-Reactive Protein (CRP) is produced in the liver in response to inflammation; its job in the body is to attach itself to phosphocholine (a chemical produced by both microbes and cells that are dying) to “flag” the unwanted cells for the immune system to remove.
If there’s an actual infection or injury present, inflammation and the resulting high CRP aren’t such a bad thing — you want your immune system to be activated so it can find and eliminate bacteria or dead and injured tissue — but in heart disease and other chronic illnesses, the high level of CRP signals continual inflammation that doesn’t go away.
You might remember a 2004 TIME magazine cover story alerting the public to the clear link between inflammation and heart disease. That was when elevated CRP was first understood for its role in the development of chronic inflammation (Rifai and Ridker 2001). It was linked not only to heart disease, but also to diabetes, stroke, metabolic syndrome, and many other serious, long-term illnesses — including osteoporosis.
There are dozens of studies that have looked at CRP levels in individuals with low bone density and osteoporosis and they have found a clear relationship between high CRP and weak or thin bones (Ganesan et al. 2005; de Pablo et al. 2012). Interestingly, there was a greater relationship between bone weakness and CRP than bone density. One study (Schett et al. 2006) concluded that “hs-CRP level is a significant and independent risk predictor of non-traumatic fracture. This finding is consistent with the hypothesis of a tight interplay between low-grade inflammation and bone turnover.” And where osteoporosis coexists with other inflammatory conditions, like emphysema, CRP highlights that association too (Samaria and Bhatia 2015).
C-Reactive Protein is such an important marker that I even include it on my Medical Tests for Osteoporosis work up that I give to all my clients. You can learn more about these tests and their meaning in my Osteo Lab Tests Online Course .
I encourage you to learn more about keeping your heart and bones healthy, including the amazing benefits that vitamin K2 offers your heart and your bones. Read my blog — Is vitamin K2 your body’s best buddy? — for more.
de Pablo, P., M. S. Cooper, and C. D. Buckley. 2012. Association between bone mineral density and C‐reactive protein in a large population‐based sample. Arthritis Rheum. 64(8):2624–2631.
Ganesan, K., et al. 2005. Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females. J Natl Med Assoc. 97(3):329–333.
He, L. P., et al. 2010. Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: A meta-analysis of longitudinal studies. Heart 96(5):339-346.
Jaffe, R., and J. Mani. 2014. Predictive biomarkers in personalized laboratory diagnosis and evidence based best practices outcome monitoring. Townsend Letter, Jan 2014.
Li, Y. W., et al. 2017. Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis. Atherosclerosis. 259:75-82.
Rifai, N., and P. M. Ridker. 2001. High-sensitivity C-reactive protein: A novel and promising marker of coronary heart disease. Clin Chem. 47(3):403-411.
Samaria, J. K., and M. Bhatia. 2015. Raised CRP levels associated with osteoporosis in patients with COPD. Am J Respir Crit Care Med. 191:A5716.
Schett, G., et al. 2006. High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck Study. Arch Intern Med. 166(22):2495-2501.
Xu, W. X., et al. 2015. High-sensitivity CRP: Possible link between job stress and atherosclerosis. Am J Ind Med. 58(7):773-779.