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Forteo follow-up: Three reports of osteosarcoma using this drug

If you saw my earlier blog on the osteoporosis drug Forteo™, you will recall that the drug was found to cause a rare, serious bone cancer (osteosarcoma) in rodents, but drug proponents suggested such cancers would not occur in humans. But this week I found that there have already been three reported cases of this rare bone cancer developing in people on Forteo.

The most recent case was detailed in an abstract (# SU0345) presented at the annual meeting of the American Society for Bone Mineral Research in Denver, from which I just returned. This is the third case in the recent literature. The first case of osteosarcoma associated with Forteo use was published in the Journal of Bone Mineral Research in 2007 (JBMR vol. 22, p. 334), and a second case was published on-line in Osteoporosis International on the 14th of July, 2009.

These unfortunate findings really drew my attention, as I had been wondering just how long it would take to find that this drug could indeed cause bone cancer in humans, just as it did in animals. Hopefully the rate of such a serious adverse events will be smaller than it was in rodents. It just makes me want to reiterate my slogan “Better Bones, Better Body” — if at all possible, everything we do for bone should be good for our entire body. There is a better way to bone health than through using drugs with such dreadful potential side effects, and I am committed to helping you develop an effective and life-supporting approach to bone health.

 

We created the Osteo Blast blog as our forum to express opinions and educate the public about natural means of supporting and improving bone health and overall wellness. As part of this forum, we sometimes discuss medical issues and medications, and their effects on bone health in general. However, we cannot advise readers about specific medical issues in this forum. If you wish to obtain advice from Susan E. Brown, PhD, about your specific bone health and nutritional concerns, please visit our Consultations page. Other specific medical questions should be referred to your healthcare provider.

Comments

April 30. 2010 14:50

Will you address the issue of whether the incidence of osteosarcoma is indeed higher in Forteo-users, than in the general population of non-users?  My understanding from researching this is that it does not occur at a higher rate; not sure how accurate this is.  If it is accurate, can it be reasonably-concluded that Forteo is indeed causing osteosarcoma in these individuals?

Thanks so much!

RJS

Rebecca J Strasser

June 3. 2010 01:07

Please provide more detail as to how I can get copies of these journal articles.  I have done online searches, but cannot find them.  It is very important to read the details rather than just giving a global finding, since I am currently on Forteo.  I need to read exactly how the research was done and the specifics of the findings.  (Please opt me out of emailing lists. Thanks.)

DS

June 3. 2010 09:21

Dear DS,

In answer to your questions:

1) The Journal of Bone and Mineral Research is published by Wiley and is available on-line through Wiley Interscience. You will need to purchase access to the article. Alternatively, if you are anywhere near a medical school or a university that has a comprehensive science program, you might be able to visit their library and make a photocopy.

2) I attempted to opt you out of our newsletter emails, but our system has no record of the email you entered into the blog for any of our newsletters. If you are using another email address and wish to opt out, there is a line reading "If you don't want to get [newsletter] anymore, please take a moment to remove your name from our list." The last six words link to our opt-out page here: www.betterbones.com/subscriberoptions/optout.aspx (if for some reason that link is broken, please copy and paste this URL into your browser).

Managing Editor

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