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Home > OEP Research & Publications > Completed Research > Clinical Studies > Advacal

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Advacal

Vitamin D & K Clinical Studies Acid/Alkaline Studies Overview of OEP's Completed Research Cal-Vantage Young Bones Ntx OsteOrganiCAL Ipriflavone Advacal OEP Articles Overview of OEP's Completed Research OEP's Current Research Overview of OEP Research & Publications

Advacal (AAACa)
Over the years there has been considerable attention given to the use issue of calcium effectiveness and bioavalability. In this small (N11), four week pilot study, the novel Japanese form of calcium (AAACa) was compared with calcium citrate. The end points of this pilot study were alterations to bone resorption, intact parathyroid hormone and first morning urine pH.

In each case, the subject received 900 mg of elemental calcium in a dosing regiment of 150 mg with each meal, and 450 mg at bedtime. This dosing regimen was likely an important factor in producing a consistent reduction in bone resorption within only four weeks.

In this small study formal statistical analysis was not able to detect a significant difference between the effects of these two forms of calcium on any end point studied.

From a case study perspective, however, there was a trend favoring AAACa over calcium citrate in reducing bone resorption markers. Specifically:

  • AAACa subjects as a group began with higher Dpd bone resorption markers than calcium citrate group (M 9.77 as compared to M 9.36) and ended with lower markers (M 5.4 compared to M 5.84).
  • The average reduction in Dpd from the beginning of the study to the end was greater in those using AAACa (M - 4.37) than those using calcium citrate
    ( - 3.52).
  • The average percentage change was - 43% for AAACa and - 33% for calcium citrate.
  • Using a 26% reduction in Dpd as statistically significant, all women using AAACa experienced a significant 26% decrease in Dpd. Only two of the five women on calcium citrate experienced such a 26% reduction.
  • While the group given AAACa began with a higher average Dpd reading, three of these six subjects reduced their Dpd level to near or below the ideal pre-menopausal level. On the other hand, none of the women on calcium citrate came to so closely approximate the ideal pre-menopausal level.

To read the full report of this study, please download the PDF file: A Pilot Study Comparing Advacal (AAACA) and Calcium Citrate Supplementation in Menopausal U.S. Women.

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The Osteoporosis Education Project is a division of
Leading Edge Research, Inc. A 501(c)
3
Copyright © 2002- 2004 Osteoporosis Education Project
605 Franklin Park Drive, East Syracuse, NY 13057-1610
Phone: 315.437.9384 | Fax: 315.432.9231 | Email:
info@betterbones.com
Home | Rethinking Osteoporosis | Are You At Risk? | Better Bones Program | Better Bones Nutrition Charts | Alkaline For Life | OEP Research & Publications | Support OEP | Bone Lectures | OEP Store

 

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