Nutrition & bone health
Key vitamins for bone health — folic acid and folate — forms of the water-soluble vitamin B9
by Dr. Susan E. Brown, PhD
Folic acid is another one of the B vitamins, referred to sometimes as folate (its
related anion form), or simply as vitamin B9. The most notable role folate and folic
acid play in bone health is in the detoxification
of homocysteine, an amino acid linked with inflammation and
increased fracture risk.
Anywhere from 5–50% of any given population (varying by geographic region and ethnicity)
may have genetic variants that impact their ability to optimally metabolize folate
and, thus, their ability to prevent homocysteine build-up, detoxify adequately, and
keep inflammation at bay.
Homocysteine is a compound produced as a by-product of the metabolism of the amino
acid methionine. Normally, homocysteine gets recycled as another substance or eliminated,
but excess blood levels can accumulate as a result of genetic or nutritional factors.
Excess homocysteine promotes both osteoporosis and atherosclerosis. The proper processing
of homocysteine requires folic acid. Researchers suggest that around the time of
menopause, women experience a reduced capacity to process homocysteine appropriately.
It is not known whether this is a universal trait or one found only in more developed
countries. Supplementing with folic acid has been found to improve this homocysteine
processing problem.
Deficiency of folic acid is an extremely common problem in many parts of the world
where diets of refined foods predominate. The average US intake is only about half
the RDA. Women taking oral contraceptives or estrogen replacement, as well as users
of alcohol and long-term users of anticonvulsant medications, are at special risk
for drug-induced folic acid deficiency.
Return to table
Our Personal Program is a great place to start
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- For more information about the at-home program for Better Bones, please call The
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Original Publication Date: 04/11/2000
Last Modified: 04/14/2010
Principal Author: Dr. Susan E. Brown, PhD