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Acid-alkaline balance: general research articles of interest
by Dr. Susan E. Brown, PhD
The resources listed below represent a collection of scientific articles discussing research on the overall effects of chronic, low-grade, metabolic acidosis on health. These sources provide a useful collection of observations for those interested in expanding their understanding of the health impacts of pH imbalance and the importance of acid-alkaline balance.
Alonso, A., de la Fuente, C., et al. (2004). Fruit and vegetable consumption is inversely associated with blood pressure in a Mediterranean population with a high vegetable-fat intake: the Seguimiento Universidad de Navarra (SUN) Study. Br J Nutr 92(2): 311-9. PMID: 15333163
Alpern, R.J., Sakhaee, K. (1997). The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity. Am J Kidney Dis 29(2): 291-302. PMID: 9016905
Bushinsky, D.A. (2002). Recurrent hypercalciuric nephrolithiasis—does diet help? N Engl J Med 346(2): 124-5. PMID: 11784880
Cordain, L., Miller, J.B., et al. (2000). Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets. Am J Clin Nutr 71(3): 682-92. PMID: 10702160
Demigne, C. Could minor cations and anions or other constituents such as fibers, contribute to the alkalinising properties of plant foods? 2nd International Acid-Base Symposium: Nutrition - Health - Disease, Welhenstephan, Germany. http://www.saeure-basen-forum.de/pdf/symp2006/abstracts/Demign_Christian.pdf
Eaton, S.B., Eaton, S.B., 3rd (2000). Paleolithic vs. modern diets—selected pathophysiological implications. Eur J Nutr 39(2): 67-70. PMID: 10918987
Farr, M., Garvey, K., et al. (1985). Significance of the hydrogen ion concentration in synovial fluid in rheumatoid arthritis. Clin Exp Rheumatol 3(2): 99-104. PMID: 4017318
Feely, R. A., Sabine, C.L., et al. (2004). Impact of anthropogenic CO2 on the CaCO3 system in the oceans. Science 305(5682): 362-6. PMID: 15256664
Frassetto, L. A., Todd, K.M., et al. (1998). Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. Am J Clin Nutr 68(3): 576-83. PMID: 9734733
Frassetto, L., Morris, R.C. Jr., et al. (2001). Diet, evolution and aging. The pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr 40(5): 200-13. http://www.saeure-basen-forum.de/pdf/symp2001/frassetto.pdf
Gonick, H. C., Goldberg, G., et al. (1968). Reexamination of the acid-ash content of several diets. Am J Clin Nutr 21(9): 898-903. PMID: 5675852
Hosch, M., Muser, J., Hulter, H.N., Krapf, R. (2004). Ureagenesis: evidence for a lack of hepatic regulation of acid-base equilibrium in humans. Am J Physiol Renal Physiol (286): F94-9. PMID: 14656759
Jaffe, R. (2000). Autoimmunity and cofactor replacement. Int J Integr Med 2(2).
Kiwull-Schone, H., Kalhoff, H., et al. (2001). Minimal-invasive approach to study pulmonary, metabolic and renal responses to alimentary acid-base changes in conscious rabbits. Eur J Nutr 40(5): 255-9. http://www.saeure-basen-forum.de/pdf/symp2001/kiwull_schoene.pdf
Lukaski, H.C. (2005). Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise. Am J Clin Nutr 81(5): 1045-51. PMID: 15883427
Manz, F., Remer, T., et al. (1995). Effects of a high protein intake on renal acid excretion in bodybuilders. Z Ernahrungswiss 34(1): 10-5. PMID: 7785291
Martin, H.E., Wertman, M. (1947). Serum potassium, magnesium, and calcium levels in diabetic acidosis. J Clin Invest 26(2): 217-28. PMID: 16695408
McCarty, M. (2005). Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output. Med Hypotheses 64: 380-384. PMID: 15607573
Morris, R.C., Jr., Sebastian, A. (2002). Alkali therapy in renal tubular acidosis: who needs it? J Am Soc Nephrol 13(8): 2186-8. PMID: 12138154
Queen, S. (1994). Free radical therapy: Part IV acidemia/free calcium excess. Health Realities. 13
Relman, A.S., Lennon, E.J., et al. (1961). Endogenous production of fixed acid and the measurement of the net balance of acid in normal subjects. J Clin Invest 40: 1621-30. PMID: 13740723
Remer, T., Manz, F. (2003). Paleolithic diet, sweet potato eaters, and potential renal acid load. Am J Clin Nutr 78(4): 802-3; author reply 803-4. PMID: 14522740
Robergs, R.A., Ghiasvand, F., et al. (2004). Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 287(3): R502-16. PMID: 15308499
Sabine, C.L., Feely, R.A., et al. (2004). The oceanic sink for anthropogenic CO2. Science 305(5682): 367-71. PMID: 15256665
Spiller, G.A., Bruce, B. (1998). Vegan diets and cardiovascular health [editorial; comment]. J Am Coll Nutr 17(5): 407-8. PMID: 9791835
Stratton-Phelps, M., House, J.K. (2004). Effect of a commercial anion dietary supplement on acid-base balance, urine volume, and urinary ion excretion in male goats fed oat or grass hay diets. Am J Vet Res 65(10): 1391-7. PMID: 15524326
Vormann, J., Worlitschek, M., et al. (2001). Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain. J Trace Elem Med Biol 15(2-3): 179-83. PMID: 11787986
Weisinger, J.R., Favus, M.J., et al. (1989). Regulation of 1,25-dihydroxyvitamin D3 by calcium in the parathyroidectomized, parathyroid hormone-replete rat. J Bone Miner Res 4(6): 929-35. PMID: 2610024
Wenzel, U.E.A. (2000). Membrane transport proteins and their role in acid base homeostasis. Acid-Base Metabolism: Nutrition - Health - Disease, Welhenstephan, Germany.
Wiederkehr, M.R., Kalogiros, J., Krapf, R. (2004). Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients. Nephrol Dial Transplant 19(5): 1190-97. PMID: 14993483.
Wiederseiner, J.M., Muser, J., Lutz, T., Hulter, H.N., Krapf, R. (2004). Acute metabolic acidosis: Characterization and diagnosis of the disorder and the plasma potassium response. J Am Soc Nephrol 15: 1589-1596. PMID: 15153570
Original Publication Date: 02/03/2003
Last Modified: 01/21/2009
Principal Author: Dr. Susan E. Brown, PhD