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Early New Year's prediction: drug companies move into muscles

You’ve probably heard me say it before. Muscle and bone work as one single unit — when we build muscle, we build bone. When we lose muscle, we lose bone — and, more importantly, losing muscle and bone means a higher fracture risk. As we age, we naturally lose muscle, lots of it, right along with bone. But here at the Center for Better Bones we’ve had great success encouraging the maintenance and building of muscle strength the old fashioned way: through exercise and an alkaline diet.

I recently heard a major researcher declare that, “Muscle strength was the most important determinant of hip strength.” It’s great to hear that word is getting out about the muscle and bone link, but I have a prediction to make. My early 2011 prediction is that those like us who promote a natural approach to building muscle are going to have competition. Big Pharma may muscle in on us.

The major pharmaceutical companies have been busy developing drugs to interfere with the mechanisms of bone loss, but now may turn their efforts toward developing drugs to interfere with muscle loss. And what makes me think this? Well, I have to credit my insight to a couple of things I learned at the annual ASBMR (American Seminar for Bone and Mineral Research) meeting:

      1. It appears that certain academic strength researchers may be moving to work directly for the pharmaceutical industry.

      2. An ASBMR lecture I attended mentioned genetic manipulation of a muscle growth inhibitor pathway (myostatin) as one possible avenue for drug intervention.

Why exercise to maintain muscle and bone mass when you can just take a drug? I think most of you already know the answer to that. No drug could ever replicate the whole-body benefits of regular exercise. Aside from bone and muscle strengthening, exercise reduces stress, improves cardiovascular health, boosts brain function, and reduces cancer risk — just to name a few. People of the world stand up, bulk-up, pump that iron, don a weighted vest, and walk. We naturalists are not going to take this challenge sitting down!

For tips to get you started or keep you going, read my article on exercising for bone health.

We created the Osteo Blast blog as our forum to express opinions and educate the public about natural means of supporting and improving bone health and overall wellness. As part of this forum, we sometimes discuss medical issues and medications, and their effects on bone health in general. However, we cannot advise readers about specific medical issues in this forum. If you wish to obtain advice from Susan E. Brown, PhD, about your specific bone health and nutritional concerns, please visit our Consultations page. Other specific medical questions should be referred to your healthcare provider.

We created the Osteo Blast blog as our forum to express opinions and educate the public about natural means of supporting and improving bone health and overall wellness. As part of this forum, we sometimes discuss medical issues and medications, and their effects on bone health in general. However, we cannot advise readers about specific medical issues in this forum. If you wish to obtain advice from Susan E. Brown, PhD, about your specific bone health and nutritional concerns, please visit our Consultations page. Other specific medical questions should be referred to your healthcare provider.

Comments

November 17. 2010 09:43

I was on high doses of Prednisolone for 2 years, which, according to my doctor, gave me my osteoporosis. I have now been off these steroids for 18 months - will the effects of these medications have worn off?  Will my bones be improving now they are receiving all the TLC advised by you or do the effects of steroids have a longer lasting legacy?   I have recently refused my annual Zolendronic Acid infusion (would have been my third) and am being hauled in to the hospital for interrogation by my consultant who is far from happy.   I was not happy going through another 6 months of bone and muscle pain which seemed to follow an infusion (something my consultant would not believe).  
Thank you for your wonderful advice - I think your book is so informative.  

Marilyn

Marilyn Halstead

November 17. 2010 10:09

Dear Marilyn,

The length of time that prednisolone remains active in the body varies depending on the dose (which in your case was high) and the length of time you're on it (in your case 2 years). There are other variables as well, so even after 18 months off, it might still be affecting you. Are you noticing any residual side effects, like puffiness in the face or changes in energy? If so, those are pretty good indications it's still active.

This doesn't necessarily mean you're still losing bone, though. We suggest that you ask the unhappy consultant to monitor your current bone loss via NTx or DpD testing. You can read more about those here: www.betterbones.com/bonehealth/bonebreakdowntests.aspx. If you are not currently losing bone, then you have a good rationale for trying to use "TLC" instead of bisphosphonates, particularly if you found the side effects so unpleasant. Your consultant may be unhappy with this too, but he/she is not the one who must live with the bone and muscle pain.

Managing Editor

November 22. 2010 11:00

I am really confused. I have severe osteoporosis due to past anorexia. I am still currenlty underwieght adn have never mensturated. I am getting on much better at present adn am gradually gaining weight however it is unknown as to whether I will ever muenstruate now (I am 34 years old). My eating disorder consultant is against me using bisphophonates due to all the side effects and to her knowledge has not seen any good research showing the benefits of using these drugs in patients with anorexia. SHe is also against the present use of HRT as she said it is not absorbed by the body until a cerain body fat is researched. She said he best 'medicine' is to get my weight up. I agree with her but I am also worried that I am being naive idnoring the advice of my bone consultant who wants me on bisphosphonates. Do you have any advice as I am really quite concerned?
Thanks you so much.

Rachel

November 22. 2010 15:33

Hi Rachel, I think you eating disorder consultant has you on a good path, and I agree with her assessment that weight gain is very important.  As regards to bone health be sure to have your vitamin D tested, consume all the 20 key bone nutrients and develop an alkaline diet as outlined in my Better Bones Program.  Best wishes, Susan Brown

Susan Brown

November 23. 2010 11:35

Hi Susan

Thanks you for your response. I am following an alkaline diet and take vitD and a natural calcium supplement from sea algae.
Thanks you for your help

Rachel

November 23. 2010 13:08

Susan,  I am 54 years old, post menopausal, fairly active, eat a better than average diet, and unfortunately 2 years ago was diagnosed with osteopenia.  I was on boniva, then switched to actonel for a total of 2 years.  Tests revealed that my bone mass is not worse, but not really better either.  I am seriously considering discontinuing the use of the drugs.  I have been using a soy protein product called "Revival" for the last 9 months.  I drink one of their soy shakes nearly every day (they are supposed to have the equivalent soy isoflavones as 6 glasses of soy milk!!)It is a product recommended in a book about menopause.  Because of the estrogen in the soy, it is supposed to improve bone health as well.  My question is....according to your website, soybeans are on the acid forming list.  should this concern me?  I noticed that prunes are on the acid list also, and yet they help form bone, and I've begun eating them every day as well.  What do you think?

Barbara Walker

November 25. 2010 15:47

Hello Susan,

I am 62. I recently had a bone density test. At the spine, the
T score is -2.2. This scares me because I know that -2.5 is
considered osteoporosis. The T scores at the femoral necks of the
hips are -1.3 and -1.4. I'm taking a multi vitamin, 1200 mg. of
calcium a day with vitamin D. I am now starting an alkaline
diet. I HATE to exercise. How effective is the OsteoBall just used
10 minutes a day?

Thanks,
Lola

Lola

November 29. 2010 14:29

Hi Barbara, The goal with eating an alkaline diet is to try to balance your acid-forming foods with alkaline-forming foods, which allows you to keep eating some acid-forming foods (some of which, like the prunes, have bone-building benefits that you don't want to skip simply because they're mildly acidic). So if you like the soy shakes and you feel like they're helping you, just as with the prunes, it's OK to have them, just make sure you're also getting plenty of alkalizing vegetables and beverages along with them.

As far as getting off the bone drugs are concerned, we can't really advise you on that score since we don't know your medical history, but the Surgeon General's recommendation is that bone medications should be used as the treatment of last resort for people who are losing bone rapidly, AFTER they have tried making dietary changes, increasing weight-bearing exercise, and identifying potential factors contributing to bone loss such as low vitamin D or any of a number of medical conditions that lead to osteoporosis. If your physician skipped over these two steps (as many do, unfortunately) then it would seem reasonable to talk to him or her about stopping them.

Managing Editor

November 30. 2010 18:40

I just receive new from my doctor that i have serve osteoporosis and that my bones are very failure, because last month my 9th rib was crack for no good reason. and my lower back feels at times like it wants to snap.I am so discourage, I'm only 49. but just 7 months I was in the hospital for having e-coil from the base of the brain and all the way down the whole spine,I was in the hospital for 7 weeks and was bed ridden my left side was paralze and they had to do surgery on my spine in the process I was on some heavy duty antiobio
I feel I was in good shape before my hospital visit. I refuse to to take drugs that will fix the problem and later cause me other problems. Please help me with advise.  thank you  Yvonne Rios

yvonne rios

December 1. 2010 09:59

Dear Yvonne,

Has your doctor investigated why you have severe osteoporosis? A woman your age who is otherwise in good health should not develop osteoporosis that quickly, even considering all you've gone through with your hospitalization. Please read our article on the causes of osteoporosis here: www.betterbones.com/osteoporosis/secondaryosteoporosis.aspx and work with your doctor for testing to determine the cause of your bone loss. Also, review our material on the natural approach to bone health www.betterbones.com/osteoporosis/naturalapproach.aspx to learn more about steps you can take to strengthen your bones.

I hope this is helpful. If you would like more specific information about how to develop a bone health program, please consult with Dr. Brown herself by visiting the Consultations page (the link is at the top of this web page).

Managing Editor

December 10. 2010 17:33

Hi Susan
My Bone Density test June 2009 show Osteoporosis on my left hip and Osteopenia on right hip and spine. My BD test in April 2006 was normal.   In Dec 2007 I had a total thyriodectomy, so my Armour Thyroid meds went from .75 to 120 mg.  So I think due to higher doses, menopause and family history I develop Osteoporosis.  My doctors all wanted me to take the bone drugs, I refused.  So I started to do all the research on Osteoporosis. I read your book.  For the last two years I been working out in the gym doing strength training.  I cut my caffeine intake to one cup in the morning. I also take all my supplements, my calcium, silca, Vit D, Vit K a Multi vit. and B12.  So I hope to have a good results for my June 2011 test.  I am 57 years and I feel great. Thank you for this informative website.

Nancy Moore

December 13. 2010 11:48

I have osteoporosis, worse in the spine than in the hip.  I was on fosamax and then actonel for 5 years but I have been off for 2 years.  My DEXA is only slightly more negative and I'm taking vit D and calcium.  I swim at least a half mile 4 -5 times per week (it builds muscle not bone) and walk at least 2 miles 4-5 times a week. I also do about 20 minutes of stretching and balancing exercises 4-5 times a week. I am 73 years old and have had osteoporosis since about age 50 but no fractures.  My doctor says as long as I do that much walking I don't need to lift weights which I hate.  Do you agree or do I need to add more to my exercise routine?  I hope not but I want to stay healthy. Thank you for your good work on behalf of women's health.

Barbara

January 24. 2011 10:42

Barbara, sorry to take so long to reply, the blog has stopped notifying us of comments all of a sudden! Muscle-building exercise is good for bone, and it's not necessary to lift weights to build muscle. But have you thought about wearing a weight vest while you walk? That would be an excellent way to increase your muscle building while doing something you already enjoy. We list a weight vest that Dr. Brown likes in the Shop section of the site, but there are others that you can locate online with a Google search. Be well.

Managing Editor

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